Encephalitozoon cuniculi in Rabbits: A Pathogen Your Patients Are Likely Already Carrying

E. cuniculi sits in a diagnostically uncomfortable position: it is common enough to be a reflex differential in almost any sick rabbit, but the available antemortem diagnostics are imprecise enough that a positive titer is often adjunctive rather than confirmatory. Understanding the pathology underlying clinical presentations — and what histopathology can and cannot contribute — is essential for navigating these cases well.